Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy

Volume 4 (Cancer Sensitizing Agents for Chemotherapy) 1st Edition

by Zhe-Sheng (Jason) Chen (Editor), Dong-Hua Yang (Editor)

Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy Series, focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have been used as sensitizing agents, such as EGFR, BCR-ABL, ALK and BRAF. In each chapter, readers will find comprehensive knowledge on the inhibitor and its action, including its biochemical, genetic, and molecular mechanisms' emphases. This book is a valuable source for oncologists, cancer researchers and those interested in applying new sensitizing agents to their research in clinical practice and in trials.

• Summarizes the sensitizing role of some tyrosine kinase inhibitors in existing research
• Brings recent findings in several cancer types, both experimental and clinically, with a particular emphases on underlying biochemical, genetic, and molecular mechanisms
• Provides an updated and comprehensive knowledge regarding the field of combinational cancer treatment